dyphylline

What is the most important information I should know about dyphylline?

Call your doctor right away if you experience nausea, vomiting, insomnia, restlessness, seizures, an increased heart rate, or a headache. These could be signs of too much dyphylline in your blood.

Do not start or stop smoking without your doctor's knowledge. Smoking may affect your dosage.

Do not take more of this medicine than is prescribed without consulting your doctor. Seek medical attention if you are having increasing difficulty breathing.

What is dyphylline?

Dyphylline is a bronchodilator. Dyphylline works in several ways: It relaxes muscles in your lungs and chest to allow more air in, it decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and it increases the contractions of your diaphragm to draw more air into the lungs.

Dyphylline is used to treat the symptoms of asthma, bronchitis, and emphysema.

Dyphylline may also be used for purposes other than those listed in this medication guide.

Who should not take dyphylline?

Before taking this medication, tell your doctor if you have

• a stomach ulcer;
• seizures;
• high blood pressure, a heart condition, or any type of heart disease;
• fluid in your lungs;
• a thyroid condition;
• liver disease; or
• kidney disease.

You may not be able to take dyphylline, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Dyphylline is in the FDA pregnancy category C. This means that it is not known whether dyphylline will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant.

Dyphylline passes into breast milk and could affect a nursing baby. Do not take dyphylline without first talking to your doctor if you are breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects from dyphylline. You may require a lower dose of this medication.

How should I take dyphylline?

Take dyphylline exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

You can take dyphylline with food to lessen stomach upset.

Take your doses at the same time every day to keep a constant level of dyphylline in your blood.

Shake the liquid forms of this medication well before use. To ensure that you get a correct dose, measure the liquid with a dose-measuring cup or spoon, not a regular tablespoon. If a spoon or cup is not provided with the medication and you do not have one, ask your pharmacist where you can get one.

Do not switch to another brand or a generic form of dyphylline without the approval of your doctor.

Store dyphylline at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a dyphylline overdose include nausea, vomiting, headache, insomnia, tremor (shaking hands or twitching,), restlessness, seizures, and irregular heartbeats.

What should I avoid while taking dyphylline?

Use caution when driving, operating machinery, or performing other hazardous activities. Dyphylline may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Do not start or stop smoking without the approval of your doctor. Smoking changes the way your body uses dyphylline, and you may need a dose adjustment.

Avoid changing your dose or changing the time of your daily doses.

Do not change the brand, generic form, or formulation (tablet, capsule, liquid) of dyphylline that you are taking without the approval of your doctor. Different brands or formulations may require different dosages.

Avoid eating excessive amounts of grilled or char-broiled foods. Doing so may also change the dose of dyphylline that you need.

Avoid caffeinated beverages such as coffee, tea, and cola. Dyphylline is related chemically to caffeine, and you may experience some side effects if you consume too much caffeine.

What are the possible side effects of dyphylline?

If you experience any of the following serious side effects, stop taking dyphylline and seek emergency medical attention:

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
• seizures;
• increased or irregular heartbeats; or
• severe nausea or vomiting.

Other, less serious side effects may occur although they are not common at appropriate doses. Continue to take dyphylline and talk to your doctor if you experience

• slight nausea, decreased appetite, or weight loss;
• restlessness, tremor, or insomnia; or
• headache, lightheadedness, or dizziness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect dyphylline?

Dyphylline interacts with many other drugs. Tell your doctor and pharmacist about all other medications that you are taking, including herbal remedies, vitamins, and other nonprescription items.

The following drugs may increase the levels of dyphylline in your blood, leading to dangerous side effects:

• alcohol;
• cimetidine (Tagamet, Tagamet HB);
• fluoroquinolone antibiotics such as enoxacin (Penetrex), lomefloxacin (Maxaquin), ciprofloxacin (Cipro), norfloxacin (Noroxin), and ofloxacin (Floxin);
• clarithromycin (Biaxin) and erythromycin (Ery-Tab, E.E.S., E-Mycin, others);
• disulfiram (Antabuse);
• estrogens (Ogen, Premarin, and many other types);
• fluvoxamine (Luvox);
• methotrexate (Folex, Rheumatrex);
• mexiletine (Mexitil) and propafenone (Rythmol);
• propranolol (Inderal);
• tacrine (Cognex);
• ticlopidine (Ticlid); and
• verapamil (Verelan, Calan, Isoptin).

The following drugs may decrease dyphylline levels in your blood, leading to poor asthma control:

• aminoglutethimide (Cytadren),
• carbamazepine (Tegretol),
• isoproterenol (Isuprel),
• moricizine (Ethmozine),
• phenobarbital (Luminal, Solfoton),
• phenytoin (Dilantin),
• rifampin (Rifadin), and
• sucralfate (Carafate).

Drugs other than those listed here may also interact with dyphylline or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about dyphylline written for health professionals that you may read.

What does my medication look like?

Dyphylline is available with a prescription under the brand names Dilor and Lufyllin in tablet and elixir formulations. Generic formulations of dyphylline are also available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2003 Cerner Multum, Inc. Version: 2.03. Revision date: 2/13/04.